![]() ![]() 8 – 10 In Canada, the proportion of acetaminophen-related injuries from accidental overdose increased from 27% in 2006 to 45% in 2011. 5 – 8 Although most acetaminophen overdoses are a result of deliberate self-harm, accidental overdoses represent a substantial and increasing proportion of these events. 1 – 4 Although generally safe at therapeutic doses, acetaminophen overdose is the leading cause of acute liver failure in several countries, including Australia, the United Kingdom and the United States, where it represents 50% of all reported cases. Additional measures to reduce the burden of accidental acetaminophen overdose are required.Ī cetaminophen is used by millions of people worldwide. Interpretation: Modifications to product labels did not reduce the rate of acetaminophen-related harm.
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